Mortality rates in England rose between 2011-16 for teenagers and most working-age adults under 50. Drug-related deaths, which had been falling for both sexes since 1999, increased sharply from 2012 onwards, particularly among men. Most of these deaths were “accidental poisonings”, though 17% of male drug-related deaths and 34% of female deaths were suicides. Unlike the US, the rise in accidental poisonings does not seem to be related to opiate abuse. ONS’s breakdown of the figures shows that opiate deaths (except codeine) have remained steady or even fallen, but there are rising deaths across most classes of non-opiates, including fentanyl (which is however frequently cut with heroin), anti-depressants and anti-psychotics, and above all cocaine.